Blood viscosity and you will blood pressure levels: role out of heat and you will hyperglycemia

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Conceptual

We planned a study to research the relations among blood pressure (BP), viscosity, and temperature in healthy subjects and among BP, viscosity, and glucose in diabetics. With simple random sampling method, 53 healthy and 29 diabetes mellitus (DM) type II subjects were selected. Parameters were determined with capillary viscometer and glucometer at 22°C, 36.5°C, and 39.5°C in healthy subjects, and at 22°C on diabetic patients during OGTT with 75 g of glucose. Statistical evaluations of the data were made with regression analysis, Student t test, Spearman’s correlation, and analysis of variance. When temperature decreased from 36.5°C to 22°C, blood viscosity increased %. This increase resulted in a % decrease in blood flow rate. According to the Hagen-Poiseuille equation, the required BP increase for compensation of the resulting tissue ischemia was %. Also, a % decrease in erythrocyte deformability and % increase in plasma viscosity were seen. When temperature increased from 36.5° to 39.5°C, blood viscosity decreased %. This caused % decrease in blood flow rate, and % decrease in BP, according to the equation. Erythrocyte deformability increase of 9.92% and plasma viscosity decrease of 4.99% arose from the temperature rise. There is a correlation between total data for temperatures and viscosities (r = ?0.84, P < .001). When the mean value of blood glucose increased from 100 to 400 mg/dL, viscosity increased 25% (r = 0.59, P = .002). In this state, blood flow rate decrease was 20% and BP increase for physiological compensation was 25%. Consequently, temperature, glucose and viscosity levels of blood are important factors for BP. Am J Hypertens 2001;–438 © 2001 American Journal of Hypertension, Ltd.

The purpose of our very own research should be to research the matchmaking one of temperatures, sugar focus, and you can viscosity off blood and plasma, in order to determine its effects into blood circulation pressure (BP) according to Hagen-Poiseuille’s hydrodynamics picture.

If the human circulatory system is considered as a closed system, hemodynamic equilibrium can be determined according to Poiseuille’s equation through the pressure, viscosity, flow rate, velocity of blood, and vessel diameter. Viscosity can be defined as the resistance of fluids against flow. The resistance for blood circulation includes friction between the blood elements and between the vessel lumen and blood. To make a fluid flow, the application of energy is required. Therefore, the energy of the circulatory system is spent in correlation with the viscosity level of blood. Energy forms of the circulatory system are BP and blood flow velocity. The velocity (v) and pressure of blood flow can be determined with Poiseuille’s equation as v = 1/4?L (F₁ ? F₂) (a 2 ? r 2 ), and also BP rate (Q) can be expressed from the above equation as Q = ?a 4 /8 ?L (F₁ ? F₂), where ? is the viscosity of the fluid, F₁ and F₂ are the initial and the final cross sectional pressures of blood, L is the length, a is the radius of vessel, and r is the distance from the center of the vessel for a flowing particle. 1, 2 Thus, to keep the equilibrium of the equation constant in the circulatory system, BP will increase when viscosity increases.

Bloodstream viscosity and you may blood pressure levels: role of temperatures and you may hyperglycemia

It’s been found you to ranging from % and you will % thinking out of hematocrit, the 11% escalation in hematocrit expands bloodstream viscosity of the 20%. Within this condition, according to Poiseuille’s picture, circulation rates decrease from the %, that may produce muscle ischemia. To save this new circulatory program within the equilibrium (which is, remaining the fresh new disperse speed enough and you will stopping structure ischemia), a good 20% rise in BP otherwise cuatro.66% vasodilation is required. 3 not, the human circulatory method is perhaps not a precise signed program, while the blood viscosity are changed on the absorption off restaurants otherwise medication. 4–8 Likewise, the consequences regarding dietary fat and of some drugs for the blood viscosity and you will hemodynamics such BP was indeed claimed. As the atherosclerotic ships you should never dilate sufficiently as a reaction to vasodilator medications, it’s been recommended you to increased blood viscosity is only able to be compensated having a great BP rise in such as for example facts. 9–twelve Also, the fresh relationship among BP, headache, coagulation, blood flow speed, and you will bloodstream viscosity was indeed discussed via the values off hemodynamics. 13, fourteen